Dr. Dipak Kumar Mandal, Professor & Head
dm_pcchem@yahoo.co.in, dm.chem@presidencycollegekolkata.ac.in
Area of Specialisation: Organic Chemistry

Academic Profile
BSc (Presidency College Kolkata, 1974), MSc (Calcutta University, 1976), recipient of University Gold Medal and Bhubana Mohini Gold Medal; PhD (Calcutta University, 1990) under the supervision of Professor Nirmal K. Sinha at Bose Institute, Kolkata, postdoctoral research with Professor C. Fred Brewer at Albert Einstein College of Medicine, New York, USA (1990-1993); joined the West Bengal Educational Service as a Lecturer in 1980 and became a Professor of Chemistry (WBSES) in 1997.

Areas of Interest
•  Physical Organic Chemistry: Reaction Mechanism and    Stereochemistry
•  Bioorganic Chemistry: Protein folding, Stability and
    Structure-Function Relationship

Areas of Research
•  Protein Folding: Folding, Stability and Association of Oligomeric    Carbohydratebinding Proteins
•  Molecular Recognition: Protein-Carbohydrate interaction

Ongoing Research Projects
Folding/unfolding of b-sheet proteins: Equilibrium and time-resolved studies with oligomeric lectins (CSIR- EMR II) [From April, 2007]

Studies on protein folding reactions with oligomeric lectins (CSIR-EMR I) [From February, 2007]

Folding and association of oligomeric proteins (CSIR – EMR I) [From January, 2006]

Research Group
Present Members
Anisur Rahaman Molla (JRF)
Pritha Mandal (JRF)
Sujit Ghosh (JRF/Part-time)

Former Members
Dr. Manjeer Chatterjee
Dr. Anindya Chatterjee

Selected Recent Publications
Mandal, D. K. Dynamic Stereochemistry: A simple approach to delineating relative configuration. J. Chem. Educ. 2007 84, 274-276.

Ghosh, S., and Mandal, D. K. Kinetic stability plays a dominant role in the denaturant-induced unfolding of Erythrina indica lectin. Biochim. Biophys. Acta 2006 1764, 1021-1028.

Chatterjee, A., and Mandal, D. K. Quaternary association and reactivation of dimeric concanavalin A. Int. J. Biol. Macromol. 2005 35, 103-109.

Chatterjee, M., and Mandal, D. K. Kinetic analysis of subunit oligomerization of the legume lectin soybean agglutinin. Biochemistry 2003, 42, 12217-12222.

Mandal, D. K. A unified con/dis approach to assigning stereogenic axis configuration. Bull. Chem. Soc. Jpn. 2002 75, 365-366

Teaching
UG (Honours): Reaction Mechanisms; Static and Dynamic Stereochemistry
PG: Pericyclic Reactions; Organic Photochemistry

List of Selected Publications
Mandal, D. K. Dynamic Stereochemistry: A simple approach to delineating relative configuration. J. Chem. Educ. 2007 84, 274-276.

Ghosh, S., and Mandal, D. K. Kinetic stability plays a dominant role in the denaturant-induced unfolding of Erythrina indica lectin. Biochim. Biophys. Acta 2006 1764, 1021-1028.

Chatterjee, A., and Mandal, D. K. Quaternary association and reactivation of dimeric concanavalin A. Int. J. Biol. Macromol. 2005 35, 103-109.

Chatterjee, M., and Mandal, D. K. Kinetic analysis of subunit oligomerization of the legume lectin soybean agglutinin. Biochemistry 2003, 42, 12217-12222.

Chatterjee, A., and Mandal, D. K. Denaturant-induced equilibrium unfolding of concanavalin A is expressed by a three-state mechanism and provides an estimate of its protein stability. Biochim. Biophys. Acta 2003 1648, 174-183.

Mandal, D. K. A unified con/dis approach to assigning stereogenic axis configuration. Bull. Chem. Soc. Jpn. 2002 75, 365-366.

Ghosh, M., and Mandal, D. K. Analysis of equilibrium dissociation and unfolding in denaturants of soybean agglutinin and two of its derivatives. Int. J. Biol. Macromol. 2001 29, 273-280.

Mandal, D. K. The R/S System: A new and simple approach to determining ligand priority and a unified method for the assignment and correlation of stereogenic center configuration in diverse stereoformulas. J. Chem. Educ. 2000 77, 866-869.

Mandal, D. K., Nieves, E., Bhattacharya, L., Orr, G. A., Roboz, J., Yu, Q., and Brewer, C. F. Purification and characterization of three isolectins of soybean agglutinin: Evidence for C-terminal truncation by electrospray ionization mass spectrometry. Eur. J. Biochem. 1994 221, 547-553.

Mandal, D. K., Bhattacharya, L., Koenig, S. H., Brown, R. D. III., Oscarson, S., and Brewer, C. F. Studies of the binding specificity of concanavalin A. Nature of the extended binding site for asparagine-linked carbohydrates. Biochemistry 1994 33, 1157-1162.

Mandal, D. K., Kishore, N., and Brewer, C. F. Thermodynamics of lectin- carbohydrate interactions. Titration microcalorimetry measurements of the binding of N-linked carbohydrates and ovalbumin to concanavalin A. Biochemistry 1994 33, 1149-1156.

Mandal, D. K., and Brewer, C. F. Lectin-glycoconjugate interactions. In "Lectins and Glycobiology", (Gabius, H. -J., and Gabius, S., Eds) Springer-Verlag Press, New York 1993, pp. 117-128.

Mandal, D. K., and Brewer, C. F. Differences in the binding affinities of dimeric concanavalin A (including acetyl- and succinyl derivatives) and tetrameric concanavalin A with large oligomannose type glycopeptides. Biochemistry 1993 32, 5116-5120.

Mandal, D. K., and Brewer, C. F. Interactions of concanavalin A with glycoproteins: Formation of homogeneous glycoprotein-lectin cross-linked complexes in mixed precipitation systems. Biochemistry 1992 31, 12602-12609.

Mandal, D. K., and Brewer, C. F. Cross-linking activity of the 14 kilodalton b-galactoside-specific vertebrate lectin with asialofetuin: Comparison with several galactose-specific plant lectins. Biochemistry 1992 31, 8465-8472.

Khan, M. I., Mandal, D. K., and Brewer, C. F. Interactions of concanavalin A with glycoproteins. A quantitative precipitation study of concanavalin A with the soybean agglutinin. Carbohydr. Res. 1991 213, 69-77.

Mandal, D. K., and Ray, A. K. Vibrational overtone manifold of the CH stretching modes in pyridine and nitrobenzene: An analysis of the theoretical and observed spectra in terms of structural factors. Indian J. Chem. 1991 30A, 109-112.

Sen, P. K., Lahiri, S., Chattopadhyay, G., and Mandal, D. K. Oxidation of 10-methoxy-9-anthraldehyde with various oxidizing agents in protic and aprotic media. Indian J. Chem. 1989 28B, 978-979.

Mandal, D. K., Ray, A. K., and Sinha, N. K. Physical and chemical characterization of macroglobulin from marine turtle eggwhite. Int. J. Biol. Macromol. 1989 11, 100-104.